Publications

UniFe

Simonato M, Bennett J, Boulis NM, Castro MG, Fink DJ, Goins WF, Gray SJ, Lowenstein PR, Vandenberghe LH, Wilson TJ, Wolfe JH, Glorioso JC.  Progress in gene therapy for neurological disorders.Nat Rev Neurol. 2013 May;9(5):277-91.

Galanopoulou AS, Simonato M, French J A, O'Brien TJ. Joint AES/ILAE translational workshop to optimize preclinical epilepsy research. Epilepsia. 2013 Aug;54 Suppl 4:1-2.

O'Brien TJ, Ben-Menachem E, Bertram EH 3rd, Collins SD, Kokaia M, Lerche H, Klitgaard H, Staley KJ, Vaudano E, Walker MC, SIMONATO M.  Proposal for a "phase II" multicenter trial model for preclinical new antiepilepsy therapy development. Epilepsia. 2013 Aug;54 Suppl 4:70-4.

Galanopoulou AS,  Buckmaster PS, Staley KJ, Moshé SL, Perucca E, Engel JJr,  Loscher W, Noebels JL, Pitkanen A, Stables J, White SH, O’Brien TJ, SIMONATO M. Identification of new treatments for epilepsy: issues in preclinical methodology. Epilepsia, in press.

Su T, Scardigli R, Fasulo L, Paradiso B, Barbieri M, Binaschi A, Bovolenta R, Zucchini S, Cossu G, Cattaneo A, SIMONATO M. By-stander effect on brain tissue of mesoangioblasts producing neurotrophins. Cell Transplantation, 2012;21(8):1613-27..

Su T, Paradiso B, Long YS, Liao WP, SIMONATO M. Evaluation of cell damage in organotypic hippocampal slice culture from adult mouse: a potential model system to study neuroprotection. Brain Res 1385, 68-76, 2011.

Paradiso B., Zucchini S., Su T., Bovolenta R., Berto E., Marconi P., Marzola A., Navarro Mora G., Fabene P.F., SIMONATO M. Localized overexpression of FGF-2 and BDNF in hippocampus reduces mossy fiber sprouting and spontaneous seizures up to four weeks after pilocarpine-induced status epilepticus. Epilepsia 52, 572-578, 2011.

SIMONATO M., Zucchini S. Are the neurotrophic factors a suitable therapeutic target for the prevention of epileptogenesis? Epilepsia 51(S3), 48–51, 2010.

Bovolenta R., Zucchini S., Paradiso B., Rodi D., Merigo F., Navarro Mora G., Osculati F., Berto E., Marconi P., Marzola A., Fabene P.F., SIMONATO M. Hippocampal FGF-2 and BDNF overexpression attenuates epileptogenesis-associated neuroinflammation and reduces spontaneous recurrent seizures. J Neuroinflammation, 7:81, 2010.

Paradiso B., Marconi P., Zucchini S., Berto E., Binaschi A., Bozac A., Buzzi A., Mazzuferi M, Magri E., Navarro Mora G., Rodi D., Su T., Volpi I., Zanetti L., Marzola A., Manservigi R., Fabene P.F., SIMONATO M. Localized delivery of FGF-2 and BDNF reduces spontaneous seizures in an epilepsy model. Proc Natl Acad Sci USA, 106, 7191-7196, 2009.

Zucchini S., Buzzi A., Barbieri M., Rodi D., Paradiso B., Binaschi A., Coffin J.D., Marzola A., Cifelli P., Belluzzi O., SIMONATO M. FGF-2 overexpression increases excitability and seizure susceptibility but decreases seizure-induced cell loss. J. Neurosci. 28, 13112-13124, 2008.

Chiaruttini C., Sonego M., Baj G., SIMONATO M., Tongiorgi E. BDNF mRNA splice variants display activity-dependent targeting to distinct hippocampal laminae. Mol. Cell. Neurosci. 37, 11-19, 2008.

SIMONATO M., Tongiorgi E., Kokaia M. Angels and demons: neurotrophic factors and epilepsy. Trends Pharmacol. Sci. 27, 631-638, 2006.

ULund:

Gotzsche, C.R., L. Nikitidou, A.T. Sorensen, M.V. Olesen, G. Sorensen, S.H. Christiansen, M. Angehagen, D.P. Woldbye, and M. Kokaia, Combined gene overexpression of neuropeptide Y and its receptor Y5 in the hippocampus suppresses seizures. Neurobiol Dis, 2012. 45(1): p. 288-96.

Ledri, M., L. Nikitidou, F. Erdelyi, G. Szabo, D. Kirik, K. Deisseroth, and M. Kokaia, Altered profile of basket cell afferent synapses in hyper-excitable dentate gyrus revealed by optogenetic and two-pathway stimulations. Eur J Neurosci, 2012. In press.

Nikitidou, L., I. Kanter-Schlifke, J. Dhondt, D. Lambrechts, and M. Kokaia, VEGF receptor overexpression enhance resistance to seizures in mice. PLoS ONE, under revision, 2012.

Olesen, M.V., S.H. Christiansen, C.R. Gotzsche, B. Holst, M. Kokaia, and D.P. Woldbye, Y5 neuropeptide Y receptor overexpression in mice neither affects anxiety- and depression-like behaviours nor seizures but confers moderate hyperactivity. Neuropeptides, 2012. 46(2): p. 71-9.

Olesen, M.V., S.H. Christiansen, C.R. Gotzsche, L. Nikitidou, M. Kokaia, and D.P. Woldbye, Neuropeptide Y Y1 receptor hippocampal overexpression via viral vectors is associated with modest anxiolytic-like and proconvulsant effects in mice. J Neurosci Res, 2012. 90(2): p. 498-507.

 

Kokaia, M., Seizure-induced neurogenesis in the adult brain. Eur J Neurosci, 2011. 33(6): p. 1133-8.

Ledri, M., A.T. Sorensen, F. Erdelyi, G. Szabo, and M. Kokaia, Tuning afferent synapses of hippocampal interneurons by neuropeptide Y. Hippocampus, 2011. 21(2): p. 198-211.

Sorensen, A.T., N. Rogelius, C. Lundberg, and M. Kokaia, Activity-dependent long-term plasticity of afferent synapses on grafted stem/progenitor cell-derived neurons. Exp Neurol, 2011. 229(2): p. 274-81.

Tonnesen, J., C.L. Parish, A.T. Sorensen, A. Andersson, C. Lundberg, K. Deisseroth, E. Arenas, O. Lindvall, and M. Kokaia, Functional integration of grafted neural stem cell-derived dopaminergic neurons monitored by optogenetics in an in vitro Parkinson model. PLoS ONE, 2011. 6(3): p. e17560.

Wood, J.C., J.S. Jackson, K. Jakubs, K.Z. Chapman, C.T. Ekdahl, Z. Kokaia, M. Kokaia, and O. Lindvall, Functional integration of new hippocampal neurons following insults to the adult brain is determined by characteristics of pathological environment. Exp Neurol, 2011. 229(2): p. 484-93.

Tonnesen, J., E.G. Seiz, M. Ramos, O. Lindvall, A. Martinez-Serrano, and M. Kokaia, Functional properties of the human ventral mesencephalic neural stem cell line hVM1. Exp Neurol, 2010. 223(2): p. 653-6.

Woldbye, D.P., M. Angehagen, C.R. Gotzsche, H. Elbrond-Bek, A.T. Sorensen, S.H. Christiansen, M.V. Olesen, L. Nikitidou, T.V. Hansen, I. Kanter-Schlifke, and M. Kokaia, Adeno-associated viral vector-induced overexpression of neuropeptide Y Y2 receptors in the hippocampus suppresses seizures. Brain, 2010. 133(9): p. 2778-88.

Ahlenius, H., V. Visan, M. Kokaia, O. Lindvall, and Z. Kokaia, Neural stem and progenitor cells retain their potential for proliferation and differentiation into functional neurons despite lower number in aged brain. J Neurosci, 2009. 29(14): p. 4408-19.

Kanter-Schlifke, I., L. Fjord-Larsen, P. Kusk, M. Angehagen, L. Wahlberg, and M. Kokaia, GDNF released from encapsulated cells suppresses seizure activity in the epileptic hippocampus. Exp Neurol, 2009. 216(2): p. 413-9.

Sorensen, A.T., L. Nikitidou, M. Ledri, E.J. Lin, M.J. During, I. Kanter-Schlifke, and M. Kokaia, Hippocampal NPY gene transfer attenuates seizures without affecting epilepsy-induced impairment of LTP. Exp Neurol, 2009. 215(2): p. 328-33.

Tonnesen, J., A.T. Sorensen, K. Deisseroth, C. Lundberg, and M. Kokaia, Optogenetic control of epileptiform activity. Proc Natl Acad Sci U S A, 2009. 106(29): p. 12162-7.

Trajkovska, V., M.A. Santini, A.B. Marcussen, M.S. Thomsen, H.H. Hansen, J.D. Mikkelsen, L. Arneberg, M. Kokaia, G.M. Knudsen, and S. Aznar, BDNF downregulates 5-HT(2A) receptor protein levels in hippocampal cultures. Neurochem Int, 2009. 55(7): p. 697-702.

NsGene:

L. Fjord-Larsen, P. Kusk, M. Torp, J.C. Sørensen, K. Ettrup, C.R. Bjarkam, B. Juliusson, J. Tornøe and L.U. Wahlberg. Encapsulated Cell Biodelivery of transposon-mediated high-dose NGF secretion to the Göttingen mini pig basal forebrain. Open Tissue Eng Regen Med J. 2012.

L.U. Wahlberg, G. Lind, P.M. Almqvist, P. Kusk, J. Tornøe, B. Juliusson, M. Söderman, E. Selldén, Å. Seiger, M. Eriksdotter-Jönhagen, B. Linderoth. Targeted therapy of NGF in Alzheimer’s disease with EC Biodelivery™ – A technology platform for restorative neurosurgery. J. Neurosurgery. 2012.

Tornøe J, Torp M, Jørgensen JR, Emerich DF, Thanos C, Bintz B, Fjord-Larsen L, Wahlberg LU. Encapsulated cell-based biodelivery of Meteorin is neuroprotective in the quinolinic acid rat model of neurodegenerative disease. Restor Neurol Neurosci. 2012;30(3):225-36.

Eriksdotter-Jönhagen M, Linderoth B, Lind G, Aladellie L, Almkvist O, Andreasen N, Blennow K, Bogdanovic N, Jelic V, Kadir A, Nordberg A, Sundström E,  Wahlund LO, Wall A, Wiberg M, Winblad B, Seiger A, Almqvist P, Wahlberg L. Encapsulated cell biodelivery of nerve growth factor to the Basal forebrain in patients with Alzheimer's disease. Dement Geriatr Cogn Disord. 2012;33(1):18-28.

Fjord-Larsen L, Kusk P, Emerich DF, Thanos C, Torp M, Bintz B, Tornøe J, Johnsen AH, Wahlberg LU. Increased encapsulated cell biodelivery of nerve growth factor in the brain by transposon-mediated gene transfer. Gene Ther. 2011 Nov 24.

Fjord-Larsen L, Kusk P, Tornøe J, Juliusson B, Torp M, Bjarkam CR, Nielsen MS, Handberg A, Sørensen JC, Wahlberg LU. Long-term delivery of nerve growth factor by encapsulated cell biodelivery in the Göttingen minipig basal forebrain. Mol Ther. 2010 Dec;18(12):2164-72.

Bioviron:

Jerusalinsky D, Baez MV, Epstein AL. Herpes simplex virus type 1-based amplicon vectors for fundamental research in neurosciences and gene therapy of neurological diseases. J Physiol Paris. 2012 Jan;106(1-2):2-11.